Collageneer®

Lupinus albus (white lupin) seed extract.

A proprietary lupin seed extract, trade named Collageneer^®, that serves as a multi-benefit firming active by stimulating synthesis of a high-quality collagen in the skin. it has remarkable anti-inflammatory abilities, anti-cancer qualities, and it effectively increases skin elasticity to firm and remodel the facial contour. this extract is specially synthesized to yield an ester known as lupeol, a pharmacologically active pentacyclic triterpenoid. lupeol is extracted from the coatings of sweet white lupin seeds in a patented process and holds the trade name Collageneer^®.

Lupeol is an active molecule that increases the synthesis of Collagen 1 and HSP 47 (Heat Shock Protein), a “chaperone” protein that facilitates collagen production. A clinical study showed the firmness of the skin improved by 92% and the sagging of the facial contour reduced by 72% after 42 days.¹ It also shows promise for treatment of skin damage, including thermal, chemical and radiation burns.² 

Lupeol has shown promise as a chemo preventative, meaning it may help slow the development of cancerous skin cells.³ Last but not least, lupeol is a potent anti-inflammatory and may help reduce visible signs of skin conditions such as eczema and acne.^{4, 5}

1. Collageneer® by Laboratoires Expanscience – Personal Care & Cosmetics. (2020). Retrieved March 2020, from https://www.ulprospector.com/en/na/PersonalCare/Detail/3036/91617/Collageneer
2. Malinowska M, Miroslaw B, Sikora E, Ogonowski J, Wojtkiewicz AM, Szaleniec M, et al. (2019) New lupeol esters as active substances in the treatment of skin damage. PLoS ONE 14(3): e0214216. https://doi.org/10.1371/journal.pone.0214216
3. Saleem, M., Afaq, F., Adhami, V., & Mukhtar, H. (2004). Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene, 23(30), 5203-5214. doi: 10.1038/sj.onc.1207641
4. Lucetti, D., Lucetti, E., Bandeira, M., Veras, H., Silva, A., & Leal, L. et al. (2010). Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. Journal Of Inflammation, 7(1), 60. doi: 10.1186/1476-9255-7-60
5. Kwon, H., Yoon, J., Park, S., Min, S., Kim, Y., & Park, J. et al. (2015). Activity-Guided Purification Identifies Lupeol, a Pentacyclic Triterpene, As a Therapeutic Agent Multiple Pathogenic Factors of Acne. Journal Of Investigative Dermatology, 135(6), 1491-1500. doi: 10.1038/jid.2015.29